Ramachandran, Sarada Devi; Schirmer, Katharina; Münst, Bernhard; Heinz, Stefan; Ghafoory, Shahrouz; Wölfl, Stefan; Simon-Keller, Katja; Marx, Alexander; Øie, Cristina Ionica; Ebert, Matthias P.; Walles, Heike; Braspenning, Joris; Breitkopf-Heinlein, Katja (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-21)
In this study we used differentiated adult human upcyte1
cells for the in vitro generation of
liver organoids. Upcyte1
cells are genetically engineered cell strains derived from primary
human cells by lenti-viral transduction of genes or gene combinations inducing transient
proliferation capacity (upcyte1
process). Proliferating upcyte1
cells undergo a finite number
of cell divisions, i.e., ...